Although colorectal cancer is a disease of the older population, these tumors are not infrequent before the age of 55.
Through the data of a population-based registry, we proposed giving a description of the clinical features of three groups of patients in whom the disease occurred at a relatively early age of onset (group I :<40 yr ; group II : 41-50 yr ; group III : 51-55 yr).
There were only 14 patients under the age of 40 yr (1.1% of total registered patients, n=1298 in the period 1984-1992).
Group II and III represented 5.9% and 6.0%, respectively (n=76 and 78), with minor fluctuations throughout the 9-yr period of registration.
Inherited colorectal tumors [hereditary nonpolyposis colorectal cancer (HNPCC), adenomatosis coli, and suspected HNPCC] accounted for 38.4% of group I patients (5 of 14), 17.1% of group II, 10.2% of group III, and only 3.5% of individuals older than 55 (p, for trend,<0.001).
Thus, hereditary colorectal tumors were detected significantly more often in younger individuals.
The majority of colorectal malignancies were localized in the left colon or rectum in all three groups, with a tendency (not significant) to a preferential localization in the right colon for tumors developed in group I (37% vs 18% and 14% in groups II and III, respectively).
Pathological stage and main histological types did not differ among the three groups. (...)
Mots-clés Pascal : Carcinome, Côlon, Rectum, Incidence, Relation, Age apparition, Déterminisme génétique, Localisation, Evolution, Pronostic, Etude statistique, Homme, Italie, Europe, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie
Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Incidence, Relation, Age of onset, Genetic inheritance, Localization, Evolution, Prognosis, Statistical study, Human, Italy, Europe, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0506692
Code Inist : 002B13B01. Création : 13/02/1998.