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  1. Helicobacter pylori and the birth cohort effect : Evidence of a continuous decrease of infection rates in childhood.

    Article - En anglais

    Objective 

    To investigate whether the decrease in rate of Helicobacter pylori infection in subsequent birth cohorts has continued during the last decades.

    Methods 

    Determination by ELISA of IgG H. pylori antibodies in 314 serum samples from Dutch children (age 6-8 yr, n=154) and young adolescents (age 12-15 yr, n=160), collected in 1978 and 1993.

    Results 

    The prevalence of H. pylori declined from 19% to 9% at age 6-8 yr and from 23% to 11% at age 12-15 yr.

    For the whole study population, a decline from 21% to 10% (p=0.01) was observed between 1978 and 1993.

    On the basis of these data and an incidence of infection with H. pylori of 0.3% per year during the same period, a model for both past and future prevalence rates of H. pylori in the Dutch population was calculated.

    The outcome demonstrates a decrease from more than 50% around World War II to less than 20% for the whole population around year 2040.

    Conclusions 

    H. pylori infection rates in childhood have continued to decline until recent decades, demonstrating a persistent birth cohort effect.

    This decline will result in a very low prevalence of H. pylori infection in the Dutch population during the next decades, becoming even lower as the observed decline in children and young adolescents continues.

    Mots-clés Pascal : Gastrite, Campylobactériose, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Incidence, Evolution, Population, Dosage, Séropositivité, IgG, Etude comparative, Enfant, Homme, Appareil digestif pathologie, Estomac pathologie

    Mots-clés Pascal anglais : Gastritis, Campylobacter infection, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Incidence, Evolution, Population, Assay, Seropositivity, IgG, Comparative study, Child, Human, Digestive diseases, Gastric disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0506686

    Code Inist : 002B30A01A2. Création : 13/02/1998.