Hyperhomocysteinemia is regarded as a risk factor for stroke but its pathogenetic role has not yet been established in Black patients.
We studied 24 Black patients admitted with cerebral thrombosis, and compared them with age-and sex-matched apparently healthy controls from the same community.
Total homocysteine (tHcy) (free homocysteine, protein-bound homocysteine, the disulfide homocystine and the mixed disulfide homocysteine-cysteine) concentration was 10.91 (4.95-23.05) mumol/l in the stroke patients and 8.73 (3.95-15.10) mumol/I in controls (p=0.031).
This difference could not be explained by differences in vitamin B12, vitamin B6 or folate status.
A subgroup of nine stroke patients with hypercreatininaemia (>90 mumol/1,75% of control concentrations) had significantly higher plasma tHcy concentrations [median (range) 9.10 (5.40-15.10) gmol/I] compared with controls [8.65 (3.96-13.89) mumol/I] (p=0.002).
Plasma tHcy concentrations of stroke patients with normal serum creatinine concentrations were not significantly different to those of controls.
Hyperhomocysteinemia in Black patients with stroke may be partially caused by renal insufficiency.
Therefore, while hyperhomocysteinemia may increase the risk of stroke, it is unlikely to be a primary initiating factor.
Mots-clés Pascal : Homocystinurie, Négroïde, Incidence, Accident cérébrovasculaire, Etude comparative, Analyse biochimique, Homocysteine desulfhydrase, Carbon-sulfur lyases, Lyases, Enzyme, Concentration chimique, Evaluation, Homme, République Sud Africaine, Afrique, Métabolisme pathologie, Aminoacidopathie, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie héréditaire, Enzymopathie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Activité biologique, Ethnie
Mots-clés Pascal anglais : Homocystinuria, Negroid, Incidence, Stroke, Comparative study, Biochemical analysis, Homocysteine desulfhydrase, Carbon-sulfur lyases, Lyases, Enzyme, Chemical concentration, Evaluation, Human, South Africa, Africa, Metabolic diseases, Aminoacid disorder, Nervous system diseases, Central nervous system disease, Cerebral disorder, Genetic disease, Enzymopathy, Cerebrovascular disease, Cardiovascular disease, Vascular disease, Biological activity, Ethnic group
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0506661
Code Inist : 002B22D01. Création : 13/02/1998.