A follow-up study was conducted among men and women aged 55 years and over living in the community in order to estimate the incidence of initiation of antidepressant drug use and the association with chronic diseases.
The study population consisted of 7,812 individuals.
Overall, the incidence density for starting therapy with an antidepressant drug was 13.5 per 1000 person-years.
The cumulative incidences after 1,2 and 3 years were 1.3,2.7 and 4.0%, respectively.
The incidence in women was almost twice that in men and slightly higher in participants older than 70 years than in those younger than 70 years.
The majority of the antidepressants prescribed were tricyclic antidepressants (65%), followed by selective serotonin reuptake inhibitors (23%) and other (12%) antidepressants.
Only a minority (23%) received a dose considered effective for the indication of depression.
Selective serotonin reuptake inhibitors were more often prescribed in an adequate dosage (68%) than were tricyclic antidepressants (12%) and other antidepressants (8%). Of the chronic diseases studied, only osteoarthritis and a history of stroke were predictors of initiation of antidepressant drug use after adjustment for age, sex and medical consumption.
Hypertension, history of myocardial infarction, diabetes mellitus, rheumatoid arthritis, glaucoma, cognitive impairment and Parkinson's disease were not associated with future antidepressant drug use. (...)
Mots-clés Pascal : Psychotrope, Antidépresseur, Vieillard, Homme, Utilisation, Evaluation, Maladie, Pays Bas, Europe, Prescription médicale, Epidémiologie, Démographie, Pratique professionnelle
Mots-clés Pascal anglais : Psychotropic, Antidepressant agent, Elderly, Human, Use, Evaluation, Disease, Netherlands, Europe, Medical prescription, Epidemiology, Demography, Professional practice
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0506188
Code Inist : 002B02B02. Création : 13/02/1998.