To assess whether excess mortality from cancer, malignant melanoma of the skin, and cancers of the brain and liver in particular, is associated with long term occupational exposure to polychlorinated biphenyls (PCBs).
Method-An epidemiological study of mortality was conducted among 138 905 men employed for at least six months between 1950 and 1986 at five electrical power companies in the United States.
Exposures were assessed by panels composed of workers, hygienists, and managers at each company, who considered tasks performed by workers in 28 job categories and estimated weekly exposures in hours for each job.
Poisson regression was used to examine mortality in relation to exposure to electrical insulating fluids containing PCBs, controlling for demographic and occupational factors.
Result-Neither an cause nor total cancer mortality was related to cumulative exposure to PCB insulating fluids.
Mortality from malignant melanoma increased with exposure ; rate ratios (RRs) relative to unexposed men for melanoma were 1.23 (95% confidence interval (95% CI) 0.56 to 2.52), 1.71 (0.68 to 4.28) and 1.93 (0.52 to 7.14) for men with<2000,>2000-10 000, and>10 000 hours of cumulative exposure to PCB insulating fluids, respectively, without consideration of latency.
Lagging exposure by 20 years yielded RRs of 1.29 (0.76 to 2.18), 2.56 (1.09 to 5.97), and 4.81 (1.49 to 15.50) for the same exposure levels. (...)
Mots-clés Pascal : Centrale électrique, Exposition professionnelle, Médecine travail, Homme, Biphényle(polychloro), Toxicité, Carcinogène, Tumeur maligne, Mortalité, Epidémiologie, Mélanome malin, Etats Unis, Amérique du Nord, Amérique, Peau pathologie
Mots-clés Pascal anglais : Electric power plant, Occupational exposure, Occupational medicine, Human, Polychlorobiphenyl, Toxicity, Carcinogen, Malignant tumor, Mortality, Epidemiology, Malignant melanoma, United States, North America, America, Skin disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0504016
Code Inist : 002B04B. Création : 13/02/1998.