Outcome determinants for isocyanate induced occupational asthma among compensation claimants.
To compare the outcome of occupational asthma (OA) induced by isocyanates in Ontario (where a surveillance programme for exposed workers has been in place for over 15 years), with the outcome of OA induced by other work agents.
Method-Compensated OA claims during the period 1984-88 in Ontario were retrospectively reviewed in a standardised way.
Result-136/235 compensated claims were attributed to isocyanates.
Compared with other causes of OA, those attributed to isocyanates had a shorter latent period before onset (5.9 v 7.9 years, P<0.05), shorter duration of symptoms before diagnosis (2.0 v 3.0 years, P<0.05), and less associated atopy (43% v 58%, P<0.05).
Outcome at a mean of 1.9 years after initial assessment was significantly better in those with OA induced by isocyanates ; 73% cleared or improved v 56% with other causes of OA (P<0.05).
Ten subjects with OA induced by isocyanates stayed at the same work ; none cleared and four had worsened at follow up.
A better outcome in OA induced by isocyanates was associated with early diagnosis (P<0.05), and early removal from isocyanates after the onset of asthma.
Conclusions-The outcome in the group with OA induced by isocyanates is similar to previous follow up studies.
However, it is better than the outcome in our comparison group with OA due to other causes, perhaps because of earlier diagnosis in the group with OA induced by isocyanates. (...)
Mots-clés Pascal : Isocyanate, Toxicité, Homme, Asthme, Exposition professionnelle, Médecine travail, Ontario, Canada, Amérique du Nord, Amérique, Pronostic, Appareil respiratoire pathologie, Bronchopneumopathie obstructive
Mots-clés Pascal anglais : Isocyanates, Toxicity, Human, Asthma, Occupational exposure, Occupational medicine, Ontario, Canada, North America, America, Prognosis, Respiratory disease, Obstructive pulmonary disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0503960
Code Inist : 002B06C02. Création : 13/02/1998.