To measure the effect of the human immunodeficiency virus (HIV) epidemic on mortality from opportunistic infections (OIs) in 1993, national multiple-cause death certificate data were examined using two approaches.
First, for each OI, the percentage of deaths with HIV infection reported as the underlying cause was calculated.
Second, the age-adjusted rate of death per million population was compared with the rate predicted from a model of rates in 1970-1980 or 1979-1981, as available.
The percentage of deaths with HIV as the underlying cause and the ratio of observed to predicted death rates were as follows :
toxoplasmosis, 91% and 86 (5.24/0.06) ;
cryptosporidiosis/isosporiasis, 90% and infinite (1.61/0.00) ;
progressive multifocal leukoencephalopathy, 87% and 19 (2.58/0.13) ;
pneumocystosis, 82% and 18 (15.44/0.87) ;
cytomegalovirus disease, 82% and 17 (12.60/0.74) ;
nontuberculous mycobacteriosis, 79% and 18 (15.51/0.84) ;
cryptococcosis, 76% and 4 (5.80/1.35) ;
and histoplasmosis, 68% and 6 (1.36/0.23).
Thus, the HIV epidemic has greatly increased mortality from several OIs.
Mots-clés Pascal : Infection opportuniste, Homme, Mortalité, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, SIDA, Virose, Infection, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : Opportunistic infection, Human, Mortality, Epidemiology, United States, North America, America, AIDS, Viral disease, Infection, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0502610
Code Inist : 002B06D01. Création : 13/02/1998.