Survival analysis and visual outcome in a large series of corneal transplants in India.
Aimlbackground-The public health significance of corneal transplantation in dealing with corneal blindness in the developing world would depend upon the survival rate of transplants.
This study was done to analyse the survival rate of corneal transplants in a large series in India, and to evaluate the influence of various risk factors on transplant survival.
Methods-The records of a series of 1725 cases of corneal transplants carried out during 1987-95 at a tertiary eye care institution in India were reviewed.
The Kaplan-Meier method was used to determine 5 year survival rates of corneal transplants performed for the various categories of preoperative diagnosis.
Multivariate Cox proportional hazards regression was used to assess how preoperative diagnosis, socioeconomic status, age, sex, vascularisation of host cornea, quality of donor cornea, and training status of surgeon influenced transplant survival.
The effect of these variables on visual outcome was assessed using multiple logistic regression.
The survival rates at 1,2, and 5 years for all corneal transplants performed for the first time in 1389 cases were 79.6% (95% confidence interval=77.3-81.9%), 68.7% (65.7-71.7%) and 46.5% (41.7-51.3%). The 5 year survival rate was highest if the corneal transplant was done for keratoconus (95.1% (84.8-100%)) and lowest if carried out for previous transplant failure (21.2% (13.8-28.6%)). (...)
Mots-clés Pascal : Homotransplantation, Cornée, Inde, Asie, Probabilité survie, Pronostic, Vision, Acuité visuelle, Homme, Transplantation, Chirurgie
Mots-clés Pascal anglais : Homotransplantation, Cornea, India, Asia, Survival probability, Prognosis, Vision, Visual acuity, Human, Transplantation, Surgery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0500919
Code Inist : 002B25B. Création : 13/02/1998.