Effects on birth weight and perinatal mortality of maternal dietary supplements in rural Gambia : 5 year randomised controlled trial.
To test the efficacy in terms of birth weight and infant survival of a diet supplement programme in pregnant African women through a priamry healthcare system.
5 year controlled trial of all pregnant women in 28 villages randomised to daily supplementation with high energy groundnut biscuits (4.3MJ/day) for about 20 weeks before delivery (intervention) or after delivery (control).
Chronically undernourished women (twin bearers excluded), yielding 2047 singleton live births and 35 stillbirths.
Main outcome measures
Birth weight ; prevalence of low birth weight (<2500 g) ; head circumference ; birth length ; gestational age ; prevalence of stillbirths ; neonatal and postneonatal mortality.
Supplementation increased weight gain in pregnancy and significantly increased birth weight, particularly during the nutritionally debilitating hungry season (June to October).
Weight gain increased by 201 g (P<0.001) in the hungry season, by 94 g (P<0.01) in the harvest season (November to May), and by 136 g (P<0.001) over the whole year.
The odds ratio for low birthweight babies in supplemented women was 0.61 (95% confidence interval 0.47 to 0.79, P<0.001).
Head circumference was significantly increased (P<0.01), but by only 3.1 mm.
Birth length and duration of gestation were not affected.
Supplementation significantly reduced perinatal mortality : the odds ratio was 0.47 (0.23 to 0.99, P<0.05) for stillbirths. (...)
Mots-clés Pascal : Epidémiologie, Prévalence, Gambie, Afrique, Efficacité traitement, Régime alimentaire enrichi, Mère, Gestation, Pronostic, Nouveau né, Homme, Poids naissance, Etude longitudinale, Long terme, Etat nutritionnel, Milieu rural, Mère pathologie, Foetus pathologie, Trouble nutrition
Mots-clés Pascal anglais : Epidemiology, Prevalence, Gambia, Africa, Treatment efficiency, Supplemented diet, Mother, Pregnancy, Prognosis, Newborn, Human, Birth weight, Follow up study, Long term, Nutritional status, Rural environment, Maternal diseases, Fetal diseases, Nutrition disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0500795
Code Inist : 002B20F02. Création : 13/02/1998.