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  1. Effects on birth weight and perinatal mortality of maternal dietary supplements in rural Gambia : 5 year randomised controlled trial.

    Article - En anglais


    To test the efficacy in terms of birth weight and infant survival of a diet supplement programme in pregnant African women through a priamry healthcare system.


    5 year controlled trial of all pregnant women in 28 villages randomised to daily supplementation with high energy groundnut biscuits (4.3MJ/day) for about 20 weeks before delivery (intervention) or after delivery (control).


    Rural Gambia.


    Chronically undernourished women (twin bearers excluded), yielding 2047 singleton live births and 35 stillbirths.

    Main outcome measures 

    Birth weight ; prevalence of low birth weight (<2500 g) ; head circumference ; birth length ; gestational age ; prevalence of stillbirths ; neonatal and postneonatal mortality.


    Supplementation increased weight gain in pregnancy and significantly increased birth weight, particularly during the nutritionally debilitating hungry season (June to October).

    Weight gain increased by 201 g (P<0.001) in the hungry season, by 94 g (P<0.01) in the harvest season (November to May), and by 136 g (P<0.001) over the whole year.

    The odds ratio for low birthweight babies in supplemented women was 0.61 (95% confidence interval 0.47 to 0.79, P<0.001).

    Head circumference was significantly increased (P<0.01), but by only 3.1 mm.

    Birth length and duration of gestation were not affected.

    Supplementation significantly reduced perinatal mortality : the odds ratio was 0.47 (0.23 to 0.99, P<0.05) for stillbirths. (...)

    Mots-clés Pascal : Epidémiologie, Prévalence, Gambie, Afrique, Efficacité traitement, Régime alimentaire enrichi, Mère, Gestation, Pronostic, Nouveau né, Homme, Poids naissance, Etude longitudinale, Long terme, Etat nutritionnel, Milieu rural, Mère pathologie, Foetus pathologie, Trouble nutrition

    Mots-clés Pascal anglais : Epidemiology, Prevalence, Gambia, Africa, Treatment efficiency, Supplemented diet, Mother, Pregnancy, Prognosis, Newborn, Human, Birth weight, Follow up study, Long term, Nutritional status, Rural environment, Maternal diseases, Fetal diseases, Nutrition disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0500795

    Code Inist : 002B20F02. Création : 13/02/1998.