The objective was to determine whether there might be an association between hepatitis C virus (HCV) chronic infection and fibromyalgia (FM).
We determined the prevalence of HCV infection in 112 FM patients, in comparison with matched rheumatoid arthritis (RA) patients from the out-patient clinic of a teaching tertiary care general hospital.
Furthermore, we looked for evidence of FM in 58 patients diagnosed with chronic hepatitis due to HCV, compared with matched surgery clinic patients.
HCV antibodies were determined by enzyme-linked immunosorbent assay (ELISA) and recombinant immunoblot assay (RIBA).
Serum RNA of HCV (HCV-RNA) was determined by polymerase chain reaction.
In the group of FM patients, HCV antibodies were found by ELISA in 17 (15.2%) patients and in six (5.3%) of the RA controls (P<0.05).
RIBA was positive in 16 and indeterminate in one of the FM patients.
Serum HCV-RNA was found in 13 of these FM patients.
In eight (47%) FM patients, alanine aminotransferase (ALT) was normal, although HCV-RNA was detected in four (50%) of them.
In the group of patients with chronic hepatitis due to HCV, all patients had HCV antibodies and the presence of HCV-RNA in serum.
Within these patients, 31 (53%) had diffuse musculoskeletal pain, while six (10%) fulfilled FM diagnostic criteria.
In the control group, 13/58 (22%) had diffuse musculoskeletal pain (P<0.001), whereas only one female patient (1.7%) fulfilled FM criteria (P<0.05).
Serum ALT was 51.7 ± 38. (...)
Mots-clés Pascal : Fibromyalgie, Pathogénie, Association, Hépatite virale C, Virose, Infection, Virus hépatite C, Flaviviridae, Virus, Epidémiologie, Prévalence, Diagnostic, Polyarthrite rhumatoïde, Etude comparative, Homme, Douleur, Chronique, Système ostéoarticulaire pathologie, Muscle strié pathologie, Appareil digestif pathologie, Foie pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Fibromyalgia, Pathogenesis, Association, Viral hepatitis C, Viral disease, Infection, Hepatitis C virus, Flaviviridae, Virus, Epidemiology, Prevalence, Diagnosis, Rheumatoid arthritis, Comparative study, Human, Pain, Chronic, Diseases of the osteoarticular system, Striated muscle disease, Digestive diseases, Hepatic disease, Inflammatory joint disease, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0500668
Code Inist : 002B15I. Création : 13/02/1998.