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  1. Autoantibodies against oxidized low-density lipoprotein in antiphospholipid syndrome.

    Article - En anglais

    The prevalence and clinical significance of anti-oxidized low-density lipoprotein antibodies (anti-ox-LDL) were evaluated in patients with the antiphospholipid syndrome (APS).

    Anti-ox-LDL were measured in the sera of 107 patients with APS (64 primary APS. 43 secondary to systemic lupus erythematosus) by enzyme-linked immunosorbent assay (ELISA) utilizing malondialdehyde (MDA) - modified LDL as antigen.

    In the same patients, anticardiolipin antibodies (aCL) and anti-/12-glycoprotein I antibodies (anti-bêta2GPI), were also measured.

    A positive titre of anti-ox-LDL was detected in 22% of patients, but only in 6% of control subjects (X2=12.

    P=0.0005).

    Levels of anti-ox-LDL were higher in patients with arterial thrombosis (n=58) than in those without (n=49) (P=0.0001).

    Anti-ox-LDL levels correlated weakly with those of aCL (r=0.196, P=0.043). but not with those of anti-bêta2GPI (r=0.076).

    Our findings suggest that elevated levels of anti-ox-LDL may represent another potential marker of APS, particularly of patients prone to arterial thrombosis.

    Mots-clés Pascal : Antiphospholipide syndrome, Anticorps, Autoanticorps, Epidémiologie, Prévalence, Lipoprotéine LDL, Etat oxydé, Symptomatologie, Pathogénie, Thrombose, Artère, Homme, Thrombocyte, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Hémopathie, Immunopathologie, Maladie autoimmune, Artère pathologie

    Mots-clés Pascal anglais : Antiphospholipid antibody syndrome, Antibody, Autoantibody, Epidemiology, Prevalence, Lipoprotein LDL, Oxidized state, Symptomatology, Pathogenesis, Thrombosis, Artery, Human, Platelet, Cardiovascular disease, Vascular disease, Hemopathy, Immunopathology, Autoimmune disease, Arterial disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0500665

    Code Inist : 002B07. Création : 13/02/1998.