Risk factors for sensitisation to methyltetrahydrophthalic anhydride.
Objectives-To examine an association between specific IgE to methyltetrahydrophthalic anhydride (MTHPA) and exposure time, atopic history, smoking habits, and total IgE concentrations.
Methods-A cross sectional survey was carried out on a population of 148 workers from two condenser plants using epoxy resin with MTHPA, an acid anhydride curing agent known to cause allergy.
Using a Pharmacia CAP system with a MTHPA human serum albumin conjugate, specific IgE antibody was detected in serum from 97 (66%) out of the 148 workers exposed to MTHPA.
Stepwise multiple linear regression analysis showed a striking relation between log concentrations of specific and total IgE (P<0.0001).
Furthermore, when the workers were divided into two groups according to a cut-off point (100 IU/ml) between low and high total IgE, current smoking was significantly (P=0.025) associated with specific IgE production only in the group with low total IgE (<100 IU/ml).
Conclusions-Smoking is the most significant risk factor for raising specific IgE to MTHPA in the group with low total IgE concentrations.
Mots-clés Pascal : Anhydride organique, Toxicité, IgE, Allergie, Homme, Facteur risque, Sensibilisation, Composé chimique, Atopie, Tabagisme, Exposition professionnelle, Médecine travail, Japon, Asie, Immunopathologie, Isobenzofurane-1,3-dione(méthyltétrahydro)
Mots-clés Pascal anglais : Organic anhydride, Toxicity, IgE, Allergy, Human, Risk factor, Sensitization, Chemical compound, Atopy, Tobacco smoking, Occupational exposure, Occupational medicine, Japan, Asia, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0494550
Code Inist : 002B06C05. Création : 03/02/1998.