Allylmercapturic acid as urinary biomarker of human exposure to allyl chloride.
To evaluate the use of urinary mercapturic acids as a biomarker of human exposure to allyl chloride (3-chloropropene) (AC).
During three regular shut down periods in a production factory for AC, both types of variables were measured in 136 workers involved in maintenance operations.
Methods-Potential airborne exposure to AC was measured by personal air monitoring in the breathing zone.
In total 205 workshifts were evaluated.
During 99 workshifts no respiratory protection equipment was used.
Mercapturic acid metabolites were measured in urinary extracts by gas chromatography-mass spectrometry (GC-MS).
During 86 work shifts when no respiratory protection was used the air concentrations of AC were below the Dutch eight hour time weighted average (8h-TWA) occupational exposure limit (OEL) of AC (3 mg/m3), whereas in 13 workshifts the potential exposure, as measured by personal air monitoring, exceeded the OEL (3.3 to 17 mg/m3).
With the aid of GC-MS, 3-hydroxy-propylmercapturic acid (HPMA) was identified as a minor and allylmercapturic acid (ALMA) as a major metabolite of AC in urine samples from the maintenance workers exposed to AC.
The concentrations of ALMA excreted were in a range from<25 mug/l (detection limit) to 3550 mug/l. The increases in urinary ALMA concentrations during the workshifts correlated well with the 8h-TWA air concentrations of AC (r=0.816, P=0.0001, n=39). (...)
Mots-clés Pascal : Composé allylique, Chlore Composé organique, Exposition professionnelle, Médecine travail, Homme, Surveillance biologique, Marqueur biologique, Propène(3-chloro), Allyle chlorure
Mots-clés Pascal anglais : Allylic compound, Chlorine Organic compounds, Occupational exposure, Occupational medicine, Human, Biological monitoring, Biological marker
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0494548
Code Inist : 002B03L06. Création : 03/02/1998.