Objectives-To investigate whether employment in dry cleaning, and potential exposure to perchloroethylene (PCE), were associated with increased risk of carcinoma of the oral cavity and pharynx, larynx, oesophagus, and gastric cardia.
Methods-Two population based case-control studies were carried out.
There were 491 cases of carcinoma of the oral cavity and pharynx, 235 of the larynx, and 404 of the oesophagus and gastric cardia. 724 controls were selected by random digit dialing.
Personal interviews ascertained information on lifetime job histories, cigarette use, alcohol consumption, and other potential risk factors.
The probability and level of exposure to PCE were estimated from the scientific literature.
People who worked in dry cleaning tended to consume less alcohol and cigarettes than the general population.
The adjusted odds ratio (OR) associated with ever having worked in dry cleaning was 1.6 (95% confidence interval (95% CI)=0.6 to 4.4) for all cancer types together.
The strongest associations were with laryngeal (OR 2.7 ; 95% CI 0.6 to 10.9) and oesophageal squamous cell carcinomas (OR 3.6 ; 95% CI 0.5 to 27.0).
For laryngeal cancer, the relative risk increased with number of years employed in the dry cleaning industry.
(P=0.14. The two cases of oesophageal squamous cell carcinomas had worked in dry cleaning for only a short time. Analyses of subsites showed higher risks for supraglottic laryngeal cancer (OR 5.7 ; 95% CI 1.0 to 32. (...)
Mots-clés Pascal : Nettoyage, Exposition professionnelle, Médecine travail, Solvant organique, Toxicité, Carcinogène, Tumeur maligne, Cavité buccale, Larynx, Oesophage, Ethylène(tétrachloro), Homme, ORL pathologie, Appareil digestif pathologie, Appareil respiratoire pathologie, Nettoyage à sec
Mots-clés Pascal anglais : Cleaning, Occupational exposure, Occupational medicine, Organic solvent, Toxicity, Carcinogen, Malignant tumor, Oral cavity, Larynx, Esophagus, Ethylene(tetrachloro), Human, ENT disease, Digestive diseases, Respiratory disease, Dry cleaning
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0494510
Code Inist : 002B10B01. Création : 03/02/1998.