Risk of congenital anomalies in children of parents occupationally exposed to low level ionising radiation.
Objectives-To evaluate the risk of having a child with a congenital anomaly in relation to occupational exposure to low level ionising radiation in the pre-conception period.
Methods-A case-control study based on the Canadian congenital anomalies registry used record linkage techniques to identify congenital anomalies among male and female workers in Canada's largest electric company.
Cases were defined as parents of a child with a congenital anomaly born between April 1979 and December 1986 who had a congenital anomaly diagnosed within the first year of life.
Controls were an individually matched sample of parents of a liveborn child without an anomaly.
Risk of congenital anomaly was assessed in relation to parental exposure to ionising radiation acquired through work within a nuclear generating station of an electric power company.
Exposure was assessed according to employment, whether or not the worker was monitored for radiation exposure, and quantitative estimates of radiation dose.
Employment within the electric power industry was not associated with an increased risk of congenital anomalies in the offspring of mothers or fathers.
Risk estimates for workers monitored (those who are likely to be exposed to ionising radiation) were 1.75 (95% confidence interval (95% CI) 0.86 to 3.55) for mothers and 0.84 (95% CI 0.68 to 1.05) for fathers. (...)
Mots-clés Pascal : Dose faible, Rayonnement ionisant, Exposition professionnelle, Médecine travail, Toxicité, Tératogène, Mère, Période activité génitale, Malformation, Descendance, Homme, Etude cas témoin, Canada, Amérique du Nord, Amérique, Risque, Préconception
Mots-clés Pascal anglais : Low dose, Ionizing radiation, Occupational exposure, Occupational medicine, Toxicity, Teratogen, Mother, Sexually active period, Malformation, Progeny, Human, Case control study, Canada, North America, America, Risk
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0494072
Code Inist : 002A30E. Création : 03/02/1998.