High antibody levels to prothrombin imply a risk of deep venous thrombosis and pulmonary embolism in middle-aged men a nested case-control study.
Antibodies against phospholipid-binding plasma proteins, such as bêta2-glycoprotein I (bêta2-GPI) and prothrombin, are associated with thromboembolic events in patients with systemic lupus erythematosus and also in subjects with no evident underlying diseases.
We wanted to examine whether increased levels of antibodies to negatively-charged phospholipids (cardiolipin), to phospholipid-binding plasma proteins bêta2-GPI and prothrombin and to oxidised low-density lipoprotein (LDL) were associated with risk of deep venous thrombosis or pulmonary embolism in subjects with no previous thrombosis.
The antibodies were measured in stored serum samples from 265 cases of deep venous thrombosis of the lower extremity or pulmonary embolism occurring during a median follow-up of about 7 years and from 265 individually matched controls.
The study subjects were middle-aged men participating in a cancer prevention trial of alpha-tocopherol and beta-carotene and the cases of thromboembolic events were identified from nationwide Hospital Discharge Register.
The risk for thrombotic events was significantly increased only in relation to antiprothrombin antibodies.
As adjusted for body mass index, number of daily cigarettes and history of chronic bronchitis, myocardial infarction and heart failure at baseline, the odds ratio per one unit of antibody was 6.56 (95% confidence interval 1.73-25.0). (...)
Mots-clés Pascal : Thrombose profonde, Veine, Facteur risque, Embolie pulmonaire, Epidémiologie, Prothrombine, Autoanticorps, Anticorps, Etude cas témoin, Finlande, Europe, Age mûr, Adulte, Homme, Veine pathologie, Appareil respiratoire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Deep vein thrombosis, Vein, Risk factor, Pulmonary embolism, Epidemiology, Prothrombin, Autoantibody, Antibody, Case control study, Finland, Europe, Middle age, Adult, Human, Venous disease, Respiratory disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0493028
Code Inist : 002B12B03. Création : 03/02/1998.