Metal fume fever : Characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value.
Results from animal and preliminaryy human exposure studies have called into question whether the 5 mg/m3 8-hour time-weighted average threshold limit value (TLV for zinc oxide fume is sufficient to protect workers against metal fitme fever.
The objectives of this study were to determine the clinical effects of exposures to low concentrations of zinc oxide and to ascertain whether these exposures elevated curculating levels of specific cytokines, which could amount for the symptoms of the metal fume fever syndrome.
Thirteen resting naive subjects inhaled, on separate days, air and 2.5 and 5 mg/m 3 of furnae-generated zinc oxide fume for 2 hours Subjects recorded symptoms and temperature and had blood drawn before and after each exposure.
The mean (± SE) maximum rise in oral temperature at 6 to 12 hours after exposure was 1.4 ± 0.3°F after 5 mg/m3, of compared with 0.6 ± 0.51 after air exposure (P<0.05).
Mean temperature was also elevated after exposure to 2.5. mg/m3 zinc oxide (1.2 ± 0.3°F).
In a parallel fashion, plasma levels of interleukin 6 (IL-6), a pyrogen, were significantly elevated after exposure to 5 mg/m3 zinc oxide.
Mean lI, - 6 values (pg/mL) at pro-exj) osure and at 3 and 6 hours post-exposure were 1. 9 (± 0.6), 2. 8 (± 0. 7), and 2. 9 (+0.6), respectively, on the air day and 1.6 (± 0.6), 4.4 (± 1.2), and 6.4 (± 1.1) on the 5 mg/m3 zinc oxide day.
Zinc oxide exposure did not significantly aftect plasma levels of tumor necrosis factor. (...)
Mots-clés Pascal : Zinc Oxyde, Toxicité, Exposition professionnelle, Fièvre vapeur métallique, Médecine travail, Homme, Cytokine, Interleukine 6, Facteur nécrose tumorale, Volontaire, Normal, Symptomatologie, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Zinc Oxides, Toxicity, Occupational exposure, Metal fumes fever, Occupational medicine, Human, Cytokine, Interleukin 6, Tumor necrosis factor, Volunteer, Normal, Symptomatology, Respiratory disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0492596
Code Inist : 002B03L02. Création : 03/02/1998.