During an investigation of hantavirus pulmonary syndrome (HPS) in Paraguay in 1995, sera from persons with HPS-like illness, houshold contacts of confirmed HPS case-patients, and a sample of the area residents were analyzed by ELISA for antibodies to Sin Nombre virus (SNV).
Rodent serosurveys and analysis of precipitation records were also conducted.
Twenty-three of 24 available probable cases were SNV antibody-positive, 17 of whom were ill between July 1995 and January 1996.
Four (14.8%) of 27 case-contacts and 44 (12.8%) of 345 community residents were also seropositive.
Calomys laucha (vesper mouse) was the most common rodent species captured and the most frequently SNV-seropositive.
Rainfall in May 1995 was 10-fold greater than that seen in May over the preceding 11 years.
This 17 case-cluster represents the largest documented outbreak since HPS was first recognized in 1993.
Calomys laucha is the likely primary rodent reservoir for a SNV-like hantavirus in western Paraguay.
Fluctuations in monthly precipitation rates may have contributed to increased risk for HPS in this region.
Mots-clés Pascal : Infection, Poumon, Hantavirus, Bunyaviridae, Virus, Epidémie, Homme, Diagnostic, Répartition géographique, Epidémiologie, Poumon pathologie, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Infection, Lung, Hantavirus, Bunyaviridae, Virus, Epidemic, Human, Diagnosis, Geographic distribution, Epidemiology, Lung disease, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0489848
Code Inist : 002B05C02C. Création : 03/02/1998.