Electrophysiological investigation of central, peripheral and autonomic nerve function in workers with long-term low-level exposure to carbon disulphide in the viscose industry.
Neurotoxicity of carbon disulphide (CS2) is well known.
The air concentration at the workplace at which such adverse effects can first be observed is the subject of controversial discussion.
In a cross-sectional study on CS2-exposed workers peripheral motor and sensory nerve conduction studies, somatosensory evoked potentials, thermotesting and investigation of forced respiration sinus arryhtmia have been carried out.
The data from 222 workers exposed to CS2 in the viscose industry were evaluated and compared with data from 191 employees from the same factory with similar physical and psychological stress factors but without detectable occupational contact to neurotoxic substances.
Median exposure to CS2 was below the currently valid occupational-medical threshold limit value (MAK-value) of 10 ppm.
Multiple linear or multiple logistic regression analysis was used to check for statistical differences.
Binary evaluation (comparison of exposed persons versus controls after multiple linear regression) revealed a slightly lower value in the exposed group for the motor nerve conduction velocity (MNCV, - 0.76 m/s, median 48 m/s), but a long way from pathological thresholds.
No dose-response relationship could be found within the exposed group for any evaluation criteria of CS2-exposure.
Somatosensory evoked potentials, thermotesting and analysis of heart rate variability yielded no indication of a neurotoxic effect of CS2. (...)
Mots-clés Pascal : Carbone disulfure, Toxicité, Système nerveux pathologie, Exposition professionnelle, Médecine travail, Homme, Dose faible, Chronique, Industrie textile, Cellulose régénérée, Système nerveux périphérique, Système nerveux central, Système nerveux autonome, Polyneuropathie périphérique, Electrophysiologie, Surveillance biologique
Mots-clés Pascal anglais : Carbon disulfide, Toxicity, Nervous system diseases, Occupational exposure, Occupational medicine, Human, Low dose, Chronic, Textile industry, Cellulose hydrate, Peripheral nervous system, Central nervous system, Autonomic nervous system, Polyneuropathy, Electrophysiology, Biological monitoring
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0489322
Code Inist : 002B03L06. Création : 03/02/1998.