(1) To assess the value of urinary butoxyacetic acid (BAA) measurement for the monitoring of workers exposed to low concentration of 2-butoxyethanol (BE) ; (2) to evaluate the in vivo effect of low occupational BE exposure on the erythrocyte lineage ; and (3) to test the possible influence of genetic polymorphism for cytochrome P450 2E1 (CYP 2E1) on urinary BAA excretion rate.
Thirty-one male workers exposed to BE in a beverage package production plant were examined according to their external (BE) and internal (BAA) solvent exposure.
The effect of this exposure on erythrocyte lineage [red blood cell numeration (RBC), hemoglobin (Hb), hematocrit (Htc), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), haptoglobin (Hp), reticulocyte numeration (Ret) and osmotic resistance (OR) ], hepatic [aspartate aminotransferase (GOT), alanine aminotransferase (GPT) ] and renal [plasmatic creatinine, urinary retinol binding protein (RBP) ] parameters was also investigated.
DNA purified from whole blood was used for CYP 2E1 genotyping.
Average airborne concentration of BE was 2.91 mg/m3 (0.59 ppm) with a standard deviation of 1.30 mg/m3 (0.27 ppm).
There was a relatively good correlation between external and internal exposure estimated by measuring BAA in post-shift urine samples (average 10.4 mg/g creatinine ; r=0.55 ; P=0.0012). (...)
Mots-clés Pascal : Ethanol(2-butoxy), Solvant organique, Toxicité, Exposition professionnelle, Médecine travail, Dose faible, Surveillance biologique, Toxicogénétique, Erythrocyte, Polymorphisme, Génétique, Cytochrome P450, Hémopathie
Mots-clés Pascal anglais : Organic solvent, Toxicity, Occupational exposure, Occupational medicine, Low dose, Biological monitoring, Toxicogenetics, Red blood cell, Polymorphism, Genetics, Cytochrome P450, Hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0489319
Code Inist : 002B03L04. Création : 03/02/1998.