Background Low serum cholesterol concentrations are associated with high death rates from cancer, trauma, and infectious diseases, but the meaning of these associations remains controversial.
The present report evaluates whether low cholestercl is likely to be a causal factor for mortality from all causes or from specific causes.
Methods and Results Among 4553 Pima Indians =20 years old, a population with low serum cholesterol (median, 4.50 mmol/L), 1077 deaths occurred during a mean follow-up of 12.8 years.
Trauma was the most common cause.
The relationship between serum cholesterol measured at 2-year intervals and age-and sex-standardized mortality rates was U-shaped.
Cholesterol was related positively to mortality from cardiovascular diseases and diabetes (including nephropathy) and negatively to mortality from cancer and alcohol-related diseases.
The relationship was U-shaped for mortality from infectious diseases, and cholesterol was not related to mortality from trauma.
Change in cholesterol from one examination to the next was positively related to mortality from diabetes.
In proportional-hazards models adjusted for potential confounders, the relationship between baseline cholesterol and mortality was U-shaped for all causes and diabetes and positive for cardiovascular diseases.
Other relationships were nonsignificant.
Among 3358 subjects followed =5 years, the relationship was significant and positive only for mortality from cardiovascular diseases. (...)
Mots-clés Pascal : Cholestérol, Sérum, Autochtone, Amérique, Cardiopathie coronaire, Diabète, Tumeur maligne, Infection, Traumatisme, Alcoolisme, Facteur risque, Mortalité, Epidémiologie, Homme, Appareil circulatoire pathologie, Endocrinopathie
Mots-clés Pascal anglais : Cholesterol, Serum, Autochtonous, America, Coronary heart disease, Diabetes mellitus, Malignant tumor, Infection, Trauma, Alcoholism, Risk factor, Mortality, Epidemiology, Human, Cardiovascular disease, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0489136
Code Inist : 002B30A01A2. Création : 03/02/1998.