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  1. Fulltext. Insulin and endometrial cancer.

    Article - En anglais


    Elevated insulin levels may explain part of the increased risk of endometrial cancer observed in obese postmenopausal women.

    Circulating sex hormones and fasting C-peptide levels were measured in sera obtained from 165 postmenopausal endometrial cancer cases accrued between June 1,1987, and May 15,1990, from hospitals in Chicago, Illinois ; Hershey, Pennsylvania ; Irvine and Long Beach, California ; Minneapolis, Minnesota ; and Winston-Salem, North Carolina, and 180 community and hysterectomy controls.

    Women with a personal history of diabetes were excluded.

    Among controls, C-peptide was positively correlated with body mass index (BMI) ( (r=0.44), waist-to-thigh circumference ratio ( (r=0.24), estrone ( (r=0.18), and estradiol ( (r=0.28) (albumin-bound (r=0.45), and free (r=0.37)) and negatively correlated with sex hormone-binding globulin (r=-0.48).

    In age-adjusted analyses, the odds ratios and 95% confidence intervals for tertiles of C-peptide and endometrial cancer were, from lowest to highest : 1.0 (reference), 0.78 (95% confidence interval (Cl) 0.43-1.4), and 2.2 (95% CI 1.3-3.7).

    Further adjustment for BMI substantially attenuated the odds ratios for the highest tertile of C-peptide (odds ratio=1.2,95% Cl 0.63-2.1), and adjustment for body mass index and other risk factors for endometrial cancer eliminated the association (odds ratio=1.0,95% Cl 0.55-2.0). (...)

    Mots-clés Pascal : Tumeur maligne, Endomètre, Hyperinsulinémie, Taux, Peptide C, Indice masse corporelle, Obésité, Oestrogène, Facteur risque, Femme, Homme, Postménopause, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Insuline, Appareil génital femelle pathologie, Utérus pathologie

    Mots-clés Pascal anglais : Malignant tumor, Endometrium, Hyperinsulinemia, Rate, C-Peptide, Body mass index, Obesity, Estrogen, Risk factor, Woman, Human, Postmenopause, Epidemiology, United States, North America, America, Insulin, Female genital diseases, Uterine diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0489124

    Code Inist : 002B20C02. Création : 03/02/1998.