In 1990-1991, the prevalence of antibodies to hepatitis A virus infection (anti-HAV) was assayed by the ELISA method among 1528 apparently healthy subjects, 20-85 years old in the Republic of San Marino.
Subjects were selected from the list of residents by a random stratified sampling procedure with a proportional allocation by age, sex and district of residence.
The overall anti-HAV prevalence was 64.7% ; it increased from 28.6% in subjects 20-30 years old to 97% in those>60 years (p<0.01).
No gender difference was observed.
At the multivariate analysis age>40 years (OR : 39.5 ; 95% CI : 12.4-126) and lowest level of schooling (OR : 1.8 ; 95% CI : 1.1-2.9), which is a good indirect indicator of socio-economic status, resulted both independent predictors of anti-HAV seroposi-tivity.
These findings reflect the improved sanitation standards in this area and indicate that the proportion of non-immune adults is increasing with a higher risk of symptomatic infection in the near future.
Mots-clés Pascal : Hépatite virale A, Virose, Infection, Sérologie, Technique ELISA, IgG, Epidémiologie, Prévalence, Adulte, Homme, Saint Marin, Europe, Appareil digestif pathologie, Foie pathologie, Anticorps
Mots-clés Pascal anglais : Viral hepatitis A, Viral disease, Infection, Serology, ELISA assay, IgG, Epidemiology, Prevalence, Adult, Human, San Marino, Europe, Digestive diseases, Hepatic disease, Antibody
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0488985
Code Inist : 002B05C02G. Création : 03/02/1998.