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  1. Effect of hepatitis C and B virus infection on risk of hepatocellular carcinoma : a prospective study.

    Article - En anglais

    To assess whether there is an additive effect between chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection on the development of hepatocellular carcinoma (HCC), 400 consecutive cirrhotic patients were followed prospectively with periodic abdominal ultrasound examination and measurement of serum alpha-fetoprotein (AFP) level every 4 months.

    During a follow-up of 1185 person-years, 80 (20%) patients developed HCC, with an annual incidence of 6.8%. The annual incidence was 2.0% in patients negative for hepatitis B surface antigen (HBsAg) and antibodies to HCV (anti-HCV), 6.6% in patients with HBsAg alone, 7.0% in patients with anti-HCV alone and 13.3% in patients co-infected with HBV and HCV.

    There was a positive linear trend in the annual incidence of HCC among patients without either marker, patients with single viral infection and patients with dual viral infection (Pfortrend<0.0001).

    Cox's proportional hazard model indicated that HCV/HBV co-infection [hazard ratio (HR), 6.41 ; 95% confidence interval (Cl), 1.80-22.80], anti-HCV alone (HR, 3.74 ; 95% CI, 1.07-13.07) and HBsAg alone (HR, 4.06 ; 95% CI, 1.23-13.34) were independently risk factors of HCC.

    In conclusion, there is an additive and independent effect modification of HCV and HBV infection on HCC development.

    Mots-clés Pascal : Carcinome hépatocellulaire, Facteur risque, Epidémiologie, Hépatite virale C, Virose, Infection, Hépatite virale B, Prospective, Etude cohorte, Taiwan, Asie, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Hepatocellular carcinoma, Risk factor, Epidemiology, Viral hepatitis C, Viral disease, Infection, Viral hepatitis B, Prospective, Cohort study, Taiwan, Asia, Human, Digestive diseases, Hepatic disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0487682

    Code Inist : 002B13C01. Création : 03/02/1998.