Based on recent analytical data, total human exogenous exposure to N-nitrosamines is estimated to be 1.10 mumol/day ; the major exposure sources are the diet (0.79 mumol/day, 80-120 mug/day ; 72%), occupational exposure (0.15-0.30 mumol/day ; 25%), cigarette smoking (0.02 mumol/day, 3.4 mug/day ; 2%), and miscellaneous minor sources, including pharmaceutical products, cosmetics, indoor and outdoor air (0.001 mumol/day, 0.1 mug/day ; 1%). Excretion of apparent total N-nitroso compounds (ATNC) in healthy adults is estimated to be 1.30±1.05 mumol/day in urine and between 1.56±1.56 and 3.17±2.58 mumol/day in faeces.
The excretion of volatile N-nitrosamines (N-nitrosodimethylamine), and N-nitrosamino acids and their derivatives (N-nitrososarcosine, N-nitrosoproline, N-nitrosothiazolidine-4-carboxylic acid and N-nitroso-2-methylthiazolidine-4-carboxylic acid) accounts for approximately 0.03% and 16.0% of urinary ATNC, respectively. 4- (Methylnitrosamino) - 1- (3-pyridyl) - 1-butanol and its O-glucuronide conjugate, two metabolites of 4- (methylnitrosamino) - 1- (3-pyridyl) - 1-butanone present in urine of smokers, account for 0.2% of the urinary ATNC response ;<1.5% of the excretion of currently identified N-nitroso compounds in urine.
The remaining N-nitroso compounds excreted in urine and those present in faeces are still unidentified. (...)
Mots-clés Pascal : Composé nitroso, Exposition, Dépistage, Source rayonnement, Monitorage, Analyse biochimique, Urine, Substance endogène, Article synthèse, Homme, Revue bibliographique, Activité biologique, Organisation santé
Mots-clés Pascal anglais : Nitroso compound, Exposure, Medical screening, Radiation source, Monitoring, Biochemical analysis, Urine, Endogenous substance, Review, Human, Bibliographic review, Biological activity, Public health organization
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0484835
Code Inist : 002B03M01. Création : 03/02/1998.