Hyperinsulinemia is associated with multiple metabolic disorders including high triglyceride level, low high density lipoprotein (HDL) cholesterol level, hypertension, and impaired glucose tolerance (IGT).
This metabolic constellation is also called the insulin resistance syndrome.
All previous data on clustering of these risk factors are, however, based on insulin levels.
Therefore, the authors examined the association of insulin sensitivity estimated by means of a frequently sampled intravenous glucose tolerance test and the minimal model with the number of metabolic disorders (dyslipidemia [high triglyceride level or low HDL cholesterol level or both], hypertension, and IGT according to the World Health Organization criteria).
Of 153 nondiabetic subjects aged 53-61 years who had participated in a previous population-based study, 79 had no disorders, 55 had one disorder, 16 had two disorders, and 3 had three disorders.
Insulin sensitivity index (SI) decreased with the increasing number of disorders (4.1,3.5,1.8, and 1.4 x 10-4 min-1 muU-1 mL-1, in subjects with 0,1,2, and 3 disorders, respectively ; p<0.001 for trend).
Similarly, fasting (7.5,7.8,15.3, and 22.0 muU/mL ; p<0.001) and 2-hour insulin levels (39.9,49.0,98.7, and 149.6 muU/mL ; p<0.001) increased by the increasing number of disorders.
The relations of SI and fasting and 2-hour insulin levels with multiple metabolic disorders were independent of sex, obesity, and body fat distribution. (...)
Mots-clés Pascal : Diabète, Hyperinsulinémie, Plasma sanguin, Dyslipémie, Hypertension artérielle, Hyperglycémie provoquée, Obésité, Biométrie corporelle, Graisse, Appareil circulatoire pathologie, Epidémiologie, Facteur risque, Homme, Finlande, Europe, Insuline, Lipide, Glucose, Etude comparative, Endocrinopathie, Métabolisme pathologie
Mots-clés Pascal anglais : Diabetes mellitus, Hyperinsulinemia, Blood plasma, Dyslipemia, Hypertension, Glucose tolerance test, Obesity, Corporal biometry, Grease, Cardiovascular disease, Epidemiology, Risk factor, Human, Finland, Europe, Insulin, Lipids, Glucose, Comparative study, Endocrinopathy, Metabolic diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0478957
Code Inist : 002B12B06. Création : 03/02/1998.