Head injury and apolipoprotein E (APOE) - epsilon 4 (e4) genotype have each been associated with increased risk of Alzheimer's disease.
If APOE-e4 affects neuronal viability and branching, and if response to head injury differs in e4 patients, then the association between head injury and Alzheimer's disease may vary with the presence of the e4 allele.
The authors examined this association in a case-control study conducted between 1987 and 1995 among enrollees of the Group Health Cooperative of Puget Sound, a health maintenance organization in Seattle, Washington.
Proxy informants reported prior head injury with loss of consciousness for 32 of 349 patients with probable Alzheimer's disease and for 16 of 342 control subjects of similar age and sex who had been randomly selected from the same population (odds ratio (OR)=2.1,95% confidence interval (Cl) 1.1-3.8).
Elevated risk was observed among men (OR=4.2,95% Cl 1.5-11.5) but not among women (OR=1.1,95% Cl 0.5-2.6).
No significant variation in the head injury-Alzheimer's disease risk relation by APOE-e4 genotype was found among 230 cases and 309 controls (OR=3.1 (95% Cl 0.7-14.6) for persons with at least one e4 allele and OR=2.0 (95% Cl 0.8-5.2) for those without e4).
Neither age, education, race, type of proxy informant, nor duration of relationship with the proxy confounded the association. (...)
Mots-clés Pascal : Démence Alzheimer, Traumatisme, Crânioencéphalique, Apolipoprotéine E, Génotype, Expression génique, Epidémiologie, Facteur risque, Homme, Etats Unis, Amérique du Nord, Amérique, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative, Système ostéoarticulaire pathologie, Crâne pathologie
Mots-clés Pascal anglais : Alzheimer disease, Trauma, Craniocerebral, Apolipoprotein E, Genotype, Gene expression, Epidemiology, Risk factor, Human, United States, North America, America, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease, Diseases of the osteoarticular system, Skull disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0477616
Code Inist : 002B17G. Création : 03/02/1998.