Determination of platinum in workroom air and in blood and urine from nursing staff attending patients receiving cisplatin chemotherapy.
The use of anti-neoplastic drugs is increasing and nursing staff are evidently concerned about the risk of hazardous exposure.
General methods are available for measuring exposure to carcinogens.
These methods, however, lack specificity
One group of anti-neoplastic drugs, based on cisplatin derivatives, contain platinum, which can be analysed at low concentrations with the use of adsorptive voltammetry.
The aim of this study was to employ this technique for assessment of occupational exposure by selective determination of platinum in workroom air and in blood and urine samples from medical staff nursing cancer patients.
The voltammetric method for determination of platinum has been further developed for analysis of blood, urine and air samples.
The effects of different materials in crucibles and different acids for sample pre-treatment, and of the ashing temperature programme were investigated for optimum conditions for analysis of blood, urine and filter samples.
Occupational exposure to cisplatin derivatives was also investigated among medical staff.
Air sampling in the workroom, as well as analysis of blood and urine samples from the exposed subjects, was carried out during the process of drug preparation and administration and when attending treated patients. (...)
Mots-clés Pascal : Anticancéreux, Cisplatine, Toxicité, Personnel sanitaire, Infirmier, Homme, Exposition professionnelle, Médecine travail, Teneur air ambiant, Lieu travail, Liquide biologique, Sang, Urine, Analyse quantitative, Platine II Complexe, Surveillance biologique
Mots-clés Pascal anglais : Antineoplastic agent, Cisplatin, Toxicity, Health staff, Nurse, Human, Occupational exposure, Occupational medicine, Ambient air concentration, Work place, Biological fluid, Blood, Urine, Quantitative analysis, Platinum II Complexes, Biological monitoring
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0476979
Code Inist : 002B02U10. Création : 03/02/1998.