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  1. Raised concentration of serum bile acids following occupational exposure to halogenated solvents, 1,1,2-trichloro-1,2,2-trifluoroethane and trichloroethylene.

    Article - En anglais

    Objectives 

    The objectives of this study were threefold.

    First, to examine the hepatic effects of occupational exposure to 1,1,2-trichloro-1,2,2-trifluoroethane (FC 113) using conventional and newer tests (serum bile acids) of hepatobiliary function.

    Second, to assess the effects of altered work practices that included a reduced exposure to a different halogenated solvent (trichloroethylene) on the same parameters of liver function ; and finally, to gather further data to support or refute the contention that serum bile acid (SBA) levels could provide a sensitive biological marker of exposure to these solvents.

    Design 

    Two groups of workers (control and exposed) in an Australian steel industry participated in the study.

    The exposed group (n=5-6) comprised individuals who had either exposure to FC 113 (68.2 ± 12.6 ppm) or trichloroethylene (8.9 ± 3.1 ppm) during the application of these solvents in a cleaning procedure, whereas the control group (n=7-11) was composed of nonsolvent-exposed office workers in the same company.

    The initial investigation involved exposure to FC 113 while a follow-up study was undertaken after changes in work practices were made including replacement of FC 113 with trichloroethylene (TRI). (...)

    Mots-clés Pascal : Solvant organique, Hydrocarbure halogéné, Ethylène(trichloro), Toxicité, Exposition professionnelle, Médecine travail, Homme, Taux, Toxicocinétique, Acide biliaire, Bile, Fonction hépatique, Foie pathologie, Foie voie biliaire pathologie, Appareil digestif pathologie, Ethane(1,1,2-trichloro-1,2,2-trifluoro)

    Mots-clés Pascal anglais : Organic solvent, Halocarbon, Ethylene(trichloro), Toxicity, Occupational exposure, Occupational medicine, Human, Rate, Toxicokinetics, Bile acid, Bile, Liver function, Hepatic disease, Hepatobiliary disease, Digestive diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0476976

    Code Inist : 002B03L04. Création : 03/02/1998.



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