Do organic solvents induce changes in the dopaminergic system ? Positron emission tomography studies of occupationally exposed subjects.
The objective of this study was to test the hypothesis that long-term occupational exposure to organic solvents may effect the levels and turnover of dopamine in man.
A study was performed on 17 patients with neuropsychiatric symptoms due to occupational solvent exposure, and 11 healthy non-exposed male volunteers (controls).
Positron emission tomography (PET) was used to assess striatal dopaminergic function, using L-[11C]DOPA, [11C]nomifensine and [11C]raclopride as tracers.
The rate of dopamine synthesis was significantly increased among subjects with occupational exposure to organic solvents compared with non-exposed controls.
After controlling for the difference in age between exposed and controls, the effect of solvent exposure became less apparent and was reduced from+32% (P=0.009) to+25% (P=0.07).
There were no differences with regard to the binding of [11C]nomifensine.
Patients with and without the diagnosis of toxic encephalopathy did not differ with regard to their putaminal uptake of L-[11C]DOPA, [11C]nomiiensine and [11C]raclopride.
The data support the hypothesis that long-term exposure to organic solvents may increase the rate of dopamine synthesis in the brain without affecting the number of presynaptic terminals or postsynaptic dopamine receptors.
Mots-clés Pascal : Solvant organique, Toxicité, Transmission dopaminergique, Chronique, Homme, Exposition professionnelle, Médecine travail, Dopamine, Encéphale, Terminaison nerveuse présynaptique, Présynaptique, Postsynaptique, Tomodensitométrie, Système nerveux pathologie
Mots-clés Pascal anglais : Organic solvent, Toxicity, Dopaminergic transmission, Chronic, Human, Occupational exposure, Occupational medicine, Dopamine, Brain (vertebrata), Presynaptic nerve ending, Presynaptic, Postsynaptic, Computerized axial tomography, Nervous system diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0476975
Code Inist : 002B03L04. Création : 03/02/1998.