Hepatitis E virus (HEV) is one of the so-called'emerging'viral pathogens, whose rôle is increasingly being recognized.
To estimate the risk of HEV infection during long-term stays in HEV-endemic countries, 500 serum samples obtained from development aid workers and their family members who had spent on average 9 years in HEV-endemic regions were tested for antibodies against HEV by ELISA and Immunoblot.
We found seroprevalence rates of 5-6% with no significant differences related to gender or area of upbringing (raised in an HEV-endemic vs. nonendemic region).
Seroprevalence rates did not increase with increasing number of stays or number of expatriate years.
None of 77 children and adolescents tested was positive for anti-HEV.
The Indian subcontinent showed the highest seropositive rate with 10%. In subjects returning from West and Central Africa, East Africa, South-east Asia and Latin America seroprevalence rates were around 7%. We found a comparatively low seroprevalence rate of 2.1% for the Arab countries and the Middle East.
Our results show that there definitely is a risk for long-term expatriates to acquire HEV infection ; however, in most of our cases infection seems to have been non-or oligo-symptomatic.
Mots-clés Pascal : Hépatite virale E, Virose, Infection, Virus hépatite E, Virus, Epidémiologie, Sérologie, Prévalence, Anticorps, Travail, Zone, Endémie, Allemagne, Europe, Homme, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis E, Viral disease, Infection, Hepatitis E virus, Virus, Epidemiology, Serology, Prevalence, Antibody, Labour, Zone, Endemy, Germany, Europe, Human, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0472208
Code Inist : 002B05C02G. Création : 03/02/1998.