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  1. Incidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer.

    Article - En anglais

    Background Previous reports have indicated that 5-13 per cent of colorectal cancer is hereditary.

    However, the proportion of cases arising as a result of mutations in the hereditary non-polyposis colorectal cancer (HNPCC) genes remains to be determined.

    Methods This study is a part prospective, part retrospective review of all cases of colorectal cancer from a district hospital over 14 years.

    Some 1137 consecutive patients with colorectal cancer were questioned about their family history of cancer and details were logged on a database.

    For the past 4 years each case has been re-evaluated where possible.

    Results Some 118 patients indicated initially that they had a first-degree relative with colorectal cancer, but on re-evaluation there were significant discrepancies.

    Only three cases (0.3 per cent) occurred in families which strictly fulfilled the criteria for HNPCC and there were no cases of familial adenomatous polyposis.

    A total of 16 patients (1.4 per cent) fulfilled looser criteria for HNPCC.

    Conclusion This population-based study has shown a lower frequency of familial bowel cancer than previous studies and may reflect a lower incidence of inherited mutations in the HNPCC DNA mismatch repair genes than is currently accepted.

    Mots-clés Pascal : Carcinome, Côlon, Rectum, Etude familiale, Rétrospective, Expression génique, Mutation, Incidence, Evaluation, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie

    Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Family study, Retrospective, Gene expression, Mutation, Incidence, Evaluation, Human, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0471103

    Code Inist : 002B13B01. Création : 03/02/1998.