logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Incidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer.

    Article - En anglais

    Background Previous reports have indicated that 5-13 per cent of colorectal cancer is hereditary.

    However, the proportion of cases arising as a result of mutations in the hereditary non-polyposis colorectal cancer (HNPCC) genes remains to be determined.

    Methods This study is a part prospective, part retrospective review of all cases of colorectal cancer from a district hospital over 14 years.

    Some 1137 consecutive patients with colorectal cancer were questioned about their family history of cancer and details were logged on a database.

    For the past 4 years each case has been re-evaluated where possible.

    Results Some 118 patients indicated initially that they had a first-degree relative with colorectal cancer, but on re-evaluation there were significant discrepancies.

    Only three cases (0.3 per cent) occurred in families which strictly fulfilled the criteria for HNPCC and there were no cases of familial adenomatous polyposis.

    A total of 16 patients (1.4 per cent) fulfilled looser criteria for HNPCC.

    Conclusion This population-based study has shown a lower frequency of familial bowel cancer than previous studies and may reflect a lower incidence of inherited mutations in the HNPCC DNA mismatch repair genes than is currently accepted.

    Mots-clés Pascal : Carcinome, Côlon, Rectum, Etude familiale, Rétrospective, Expression génique, Mutation, Incidence, Evaluation, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie

    Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Family study, Retrospective, Gene expression, Mutation, Incidence, Evaluation, Human, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0471103

    Code Inist : 002B13B01. Création : 03/02/1998.