Incidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer.
Background Previous reports have indicated that 5-13 per cent of colorectal cancer is hereditary.
However, the proportion of cases arising as a result of mutations in the hereditary non-polyposis colorectal cancer (HNPCC) genes remains to be determined.
Methods This study is a part prospective, part retrospective review of all cases of colorectal cancer from a district hospital over 14 years.
Some 1137 consecutive patients with colorectal cancer were questioned about their family history of cancer and details were logged on a database.
For the past 4 years each case has been re-evaluated where possible.
Results Some 118 patients indicated initially that they had a first-degree relative with colorectal cancer, but on re-evaluation there were significant discrepancies.
Only three cases (0.3 per cent) occurred in families which strictly fulfilled the criteria for HNPCC and there were no cases of familial adenomatous polyposis.
A total of 16 patients (1.4 per cent) fulfilled looser criteria for HNPCC.
Conclusion This population-based study has shown a lower frequency of familial bowel cancer than previous studies and may reflect a lower incidence of inherited mutations in the HNPCC DNA mismatch repair genes than is currently accepted.
Mots-clés Pascal : Carcinome, Côlon, Rectum, Etude familiale, Rétrospective, Expression génique, Mutation, Incidence, Evaluation, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie
Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Family study, Retrospective, Gene expression, Mutation, Incidence, Evaluation, Human, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0471103
Code Inist : 002B13B01. Création : 03/02/1998.