We determined whether serum carotenoid or retinol concentrations were altered by p-carotene supplementation in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study and whether such effects were modified by alcohol consumption or cigarette use.
Participants in this substudy were 491 randomly selected men aged 58-76 y from the metropolitan Helsinki study center [237 receiving supplemental bêta-carotene (20 mg/d) and 254 not receiving such supplementation]. Dietary carotenoids, retinol, and alcohol, and serum bêta-carotene, alpha-tocopherol, retinol, and cholesterol were assessed at baseline.
After an average of 6.7 y of supplementation, serum was collected and carotenoid, retinol, and alpha-tocopherol concentrations were determined by HPLC.
Serum carotenoid fractions were highly correlated with each other (P ¾ 0.001).
Compared with the unsupplemented group, the bêta-carotene group had significantly higher serum concentrations of bêta-carotene (1483%), alpha-carotene (145%), and bêta-cryptoxanthin (67%) (P ¾ 0.0001).
Retinol concentrations were 6% higher (P=0.03) and lutein was 11% lower (P=0.02) in the supplemented group.
Serum lycopene, zeaxanthin, and alpha-tocopherol did not differ according to bêta-carotene-supplementation status.
Although these bêta-carotene-group differences were not significantly altered by amount of alcohol consumption, higher consumption (>12. (...)
Mots-clés Pascal : Supplémentation, Voie orale, Bétacarotène, Ethanol, Tabac, Sérum, Caroténoïde, Tumeur maligne, Prévention, Interaction tabac médicament, Interaction alcool médicament, Vitamine, Interaction toxique médicament, Homme
Mots-clés Pascal anglais : Supplementation, Oral administration, Betacarotene, Ethanol, Tobacco, Serum, Carotenoid, Malignant tumor, Prevention, Drug tobacco interaction, Drug alcohol interaction, Vitamin, Drug poison interaction, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0470591
Code Inist : 002B02N. Création : 03/02/1998.