logo BDSP

Base documentaire

  1. Fulltext. Effects of supplemental bêta-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.

    Article - En anglais


    We determined whether serum carotenoid or retinol concentrations were altered by p-carotene supplementation in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study and whether such effects were modified by alcohol consumption or cigarette use.

    Participants in this substudy were 491 randomly selected men aged 58-76 y from the metropolitan Helsinki study center [237 receiving supplemental bêta-carotene (20 mg/d) and 254 not receiving such supplementation]. Dietary carotenoids, retinol, and alcohol, and serum bêta-carotene, alpha-tocopherol, retinol, and cholesterol were assessed at baseline.

    After an average of 6.7 y of supplementation, serum was collected and carotenoid, retinol, and alpha-tocopherol concentrations were determined by HPLC.

    Serum carotenoid fractions were highly correlated with each other (P ¾ 0.001).

    Compared with the unsupplemented group, the bêta-carotene group had significantly higher serum concentrations of bêta-carotene (1483%), alpha-carotene (145%), and bêta-cryptoxanthin (67%) (P ¾ 0.0001).

    Retinol concentrations were 6% higher (P=0.03) and lutein was 11% lower (P=0.02) in the supplemented group.

    Serum lycopene, zeaxanthin, and alpha-tocopherol did not differ according to bêta-carotene-supplementation status.

    Although these bêta-carotene-group differences were not significantly altered by amount of alcohol consumption, higher consumption (>12. (...)

    Mots-clés Pascal : Supplémentation, Voie orale, Bétacarotène, Ethanol, Tabac, Sérum, Caroténoïde, Tumeur maligne, Prévention, Interaction tabac médicament, Interaction alcool médicament, Vitamine, Interaction toxique médicament, Homme

    Mots-clés Pascal anglais : Supplementation, Oral administration, Betacarotene, Ethanol, Tobacco, Serum, Carotenoid, Malignant tumor, Prevention, Drug tobacco interaction, Drug alcohol interaction, Vitamin, Drug poison interaction, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0470591

    Code Inist : 002B02N. Création : 03/02/1998.