Mixed cryoglobulinemia (MC) is a systemic disorder whose pathogenesis is based on the presence of serum cryoglobulins.
The purpose of this study was to evaluate on a prospective basis patients presenting with MC with regard to the clinical manifestations and the underlying disorders.
We present ten patients with MC, who were diagnosed and followed up during a one year period in the Division of autoimmune rheumatic diseases (Clinical Department of Pathophysiology).
MC was associated with hepatitis C virus (HCV) infection in two cases, with hepatitis B virus (HBV) infection in six, one patient had both HCV and evidence of HBV infection, while the remaining three patients fulfilled European classification criteria for diagnosis of Sjögren's syndrome (SS).
In all ten cases, the presence of an underlying factor was identified, being either viral or autoimmune.
It is concluded therefore that all patients presenting with MC should be completely evaluated for a hepatitis virus infection or an autoimmune or lymphoproliferative disorder.
Furthermore, since the initiation of the process of MC is triggered by many factors, research should be directed towards the identification of the underlying common denominator.
Mots-clés Pascal : Cryoglobulinémie mixte, Homme, Symptomatologie, Analyse biochimique, Sérum, Diagnostic, Hépatite virale, Virose, Infection, Analyse corrélation, Epidémiologie, Sjogren syndrome, Maladie système, Immunopathologie, Vaisseau sanguin pathologie, Appareil circulatoire pathologie, Capillaire sanguin pathologie, Maladie autoimmune, Appareil digestif pathologie, Foie pathologie, Oeil pathologie, Stomatologie
Mots-clés Pascal anglais : Mixed cryoglobulinemia, Human, Symptomatology, Biochemical analysis, Serum, Diagnosis, Viral hepatitis, Viral disease, Infection, Correlation analysis, Epidemiology, Sjogren syndrome, Systemic disease, Immunopathology, Vascular disease, Cardiovascular disease, Capillary vessel disease, Autoimmune disease, Digestive diseases, Hepatic disease, Eye disease, Stomatology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0466320
Code Inist : 002B07. Création : 03/02/1998.