To test the hypothesis that the increase in allergic prevalence is related not only to environmental allergens, but also to comprehensive life style, we administered to 733 workers at a hard metal plant a questionnaire that included 17 physical and mental health practices.
We have shown that eight practices are associated with increases or decreases of total and specific IgE levels, serving to keep them within the normal range (5-400 IU/ml), after controlling for age, sex, and environmental factors.
Further confirmation of the definite effect of life style on allergic reactions comes from higher heritability among younger pairs of identical twins of total IgE levels and allergic disorders than among older pairs of identical twins.
A marked synergism was found among Undesirable life-style factors as bipolar high-risk factors for the development of allergic diseases or immunosuppression characterized by low natural killer (NK) cell activity through which soluble low-affinity IgE receptor is kept low.
An effort to practice Desirable life styles, therefore, may be of benefit in reducing the risk of immunoallergic disorders.
Mots-clés Pascal : Allergie, IgE, Taux, Mode de vie, Epidémiologie, Facteur risque, Homme, Japon, Asie, Immunopathologie
Mots-clés Pascal anglais : Allergy, IgE, Rate, Life habit, Epidemiology, Risk factor, Human, Japan, Asia, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0466041
Code Inist : 002B06C01. Création : 03/02/1998.