Study objective-To examine the hypothesis that the higher rates of coronary heart disease (CHD) in Indians (South Asians) compared with Malays and Chinese is at least partly explained by central obesity, insulin resistance, and syndrome X (including possible components).
Design-Cross sectional study of the general population.
Participants-Random sample of 961 men and women (Indians, Malays, and Chinese) aged 30 to 69 years.
Main results-Fasting serum insulin concentration was correlated directly and strongly with body mass index (BMI), waist-hip ratio (WHR), and abdominal diameter.
The fasting insulin concentration was correlated inversely with HDL cholesterol and directly with the fasting triglyceride concentration, blood pressures, plasminogen activator inhibitor 1 (PAI-1), and tissue plasminogen activator (tPA), but it was not correlated with LDL cholesterol, apolipoproteins B and Al, lipoprotein (a) (Lp (a)), fibrinogen, factor VIIc, or prothrombin fragment (F) 1+2. This indicates that the former but not the latter are part of syndrome X. While Malays had the highest BMI, Indians had a higher WHR (men 0.93 and women 0.84) than Malays (men 0.91 and women 0.82) and Chinese (men 0.90 and women 0.82).
In addition, Indians had higher fasting insulin values and more glucose intolerance than Malays and Chinese. (...)
Mots-clés Pascal : Obésité, Diabète insulinorésistant, X Syndrome, Lipoprotéine a, Cardiopathie coronaire, Etude transversale, Facteur risque, Homme, Epidémiologie, Etat nutritionnel, Singapour, Asie, Ethnie, Trouble nutrition, Endocrinopathie, Appareil circulatoire pathologie, Métabolisme pathologie, Etude comparative
Mots-clés Pascal anglais : Obesity, Insulinoresistant diabetes, X Syndrome, Lipoprotein a, Coronary heart disease, Cross sectional study, Risk factor, Human, Epidemiology, Nutritional status, Singapore, Asia, Ethnic group, Nutrition disorder, Endocrinopathy, Cardiovascular disease, Metabolic diseases, Comparative study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0465850
Code Inist : 002B12A03. Création : 03/02/1998.