Epidemiological studies show that moderate alcohol consumption rather than abstention is associated with a lower risk of coronary heart disease (CHD) mortality.
Our objective was to adjust established methods for calculating attributable fractions to a situation where the risk function is J-shaped and to estimate the number of CHD deaths « caused » and « prevented » by alcohol in Finland.
Point estimates of relative risk were obtained by a meta-analysis.
They were pooled by fitting a nonparametric cubic smoothing spline to the data.
Alcohol consumption distribution was estimated from survey data (N=4,818 ; 2,488 women).
The consequences of various assumptions about changes in alcohol consumption distribution on CHD mortality were estimated.
The most detailed analyses are presented for men aged 30-69.
The results for the men and women aged 30-79 are summarized.
Among men aged 30-69, the beneficial effects of light to moderate alcohol consumption'prevent some 400 CHD deaths each year which corresponds to 12-14% of the observed CHD deaths.
Around 20 CHD deaths are « caused »by alcohol consumption exceeding the estimated optimum level.
Among men aged 70-79 and women aged 30-79, the numbers of CHD deaths « prevented »by alcohol consumption were approximately 200 and 100, respectively, whereas there were only a few CHD deaths « caused »by alcohol. (...)
Mots-clés Pascal : Cardiopathie coronaire, Mortalité, Etiologie, Consommation, Boisson alcoolisée, Prévention, Epidémiologie, Facteur risque, Sexe, Finlande, Europe, Homme, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Mortality, Etiology, Consumption, Alcoholic beverage, Prevention, Epidemiology, Risk factor, Sex, Finland, Europe, Human, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0465546
Code Inist : 002B03F. Création : 03/02/1998.