The British Nuclear Fuels plc facility at Sellafield performs a range of nuclear-related activities.
The site has been in operation since 1950 and has, in general, employed a stable work force, many of whom have accumulated relatively high occupational exposures to ionizing radiation.
This paper compares the physical dosimetry with two biological end points for evaluating radiation exposure : fluorescence in situ hybridization with whole-chromosome painting probes to quantify stable chromosome aberrations (translocations and insertions), and glycophorin A (GPA) analysis of variant erythrocytes.
For the cytogenetic analyses, 81 workers were evaluated in five dose categories, including 23 with minimal radiation exposure (<50 mSv) and 58 with exposures ranging from 173 to 1108 mSv, all but 3 being>500 mSv.
In a univariate analysis, the mean stable chromosome aberration frequencies showed a significant increase with dose category (P=0.032), and with cumulative dose when dose is treated as a continuous variable (P=0.015).
The slope of the dose response for stable aberrations is 0.79 ± 0.22 aberrations per 100 cells per sievert (adjusted for smoking status), which is less than that observed among atomic bomb survivors, and suggests a dose and dose-rate effectiveness factor for chronic exposure of about 6. Analyses of the data for GPA N/O and NIN variants from 36 workers revealed no correlation with dose. (...)
Mots-clés Pascal : Médecine travail, Chimie nucléaire, Irradiation ionisante, Royaume Uni, Europe, Aberration chromosomique, Homme, Exposition professionnelle, Corrélation, Marqueur biologique, Glycophorine A
Mots-clés Pascal anglais : Occupational medicine, Nuclear chemistry, Ionizing irradiation, United Kingdom, Europe, Chromosomal aberration, Human, Occupational exposure, Correlation, Biological marker
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0464467
Code Inist : 002B30B01B. Création : 03/02/1998.