Objectives-A previous study reported a fivefold increase in mortality from pancreatic cancer and a threefold increase in lymphopoietic and haematopoietic cancer among 278 men who were assigned to a now dismantled Union Carbide chlorohydrin unit in the Kanawha Valley of West Virginia.
There were also significant trends with duration of employment.
The purpose of this study was to determine whether a comparable increased risk in mortality from pancreatic cancer and lymphopoietic and haematopoietic cancer occurred among male employees assigned to the Dow Chemical Company's ethylene and propylene chlorohydrin production processes.
Methods-The cohort consisted of 1361 male employees who worked at the company's Freeport, Texas, Plaquemine, Louisiana or Midland, Michigan plants.
Subjects were considered to have had a minimum of 30 days of workplace experience in 1940-92, in the ethylene chlorohydrin and propylene chlorohydrin process areas.
These process areas were located within the ethylene oxide and propylene oxide production plants.
A total of 300 deaths was observed to 31 December 1992.
-The standardised mortality ratio (SMR) for all malignant neoplasms was 94 (95% CI 74 to 118).
There was one pancreatic cancer death compared with 4.0 expected (SMR 25,95% CI 1 to 140).
There were 10 lymphopoietic and haematopoietic cancer deaths compared with 7.7 expected (SMR 129,95% CI 62 to 238). (...)
Mots-clés Pascal : Toxicité, Industrie chimique, Homme, Tumeur maligne, Pancréas, Hémopathie maligne, Exposition professionnelle, Médecine travail, Carcinogène, Etude cohorte, Mortalité, Epidémiologie, Oxirane, Oxirane(méthyl), Appareil digestif pathologie, Pancréas pathologie, Ethanol(2-chloro), Prop-2-èn-1-ol(1-chloro)
Mots-clés Pascal anglais : Toxicity, Chemical industry, Human, Malignant tumor, Pancreas, Malignant hemopathy, Occupational exposure, Occupational medicine, Carcinogen, Cohort study, Mortality, Epidemiology, Ethylene oxide, Oxirane(methyl), Digestive diseases, Pancreatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0464100
Code Inist : 002B13C03. Création : 03/02/1998.