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  1. Malignant hypertension in young women is related to previous hypertension in pregnancy, not oral contraception.

    Article - En anglais

    Previous studies have suggested that one-third of women of childbearing age who develop malignant phase hypertension (MHT) are likely to be taking oral contraceptives (OC).

    We surveyed 104 women with a history of MHT.

    None of the 65 aged>45 years were taking OC or other sex hormones.

    Thirty-nine (mean age 34.9 years, SD 8.0) were aged 15-44 years at presentation : 22 Caucasian, 10 Black/Afro-Caribbean and seven Indo-Asian.

    Of these 39,22 had a history of hypertension in pregnancy (group 1), and 17 did not (group 2).

    Three of group 1 also had a history of OC-induced hypertension.

    None were pregnant, but one was taking an OC at presentation with MHT.

    Blood pressures at presentation and follow-up, and mean serum urea and creatinine at presentation were similar between groups, as was median survival (96 vs. 47 months, Lee-Desu statistic 0.75, p=0.38).

    There was a trend towards poorer renal function at follow-up in group 1 patients, with higher mean serum urea and creatinine levels.

    The causes of death were renal failure (5), stroke (4) and heart disease (2).

    The OC was not a common cause of MHT amongst our sample of women of childbearing age, but a past history of hypertension in pregnancy was important.

    Such patients also had a longer duration of hypertension and poorer renal function at follow-up.

    Mots-clés Pascal : Hypertension artérielle maligne, Association, Gestation, Enquête publique, Voie orale, Contraceptif, Etude comparative, Evaluation, Homme, Femelle, Appareil circulatoire pathologie, Vaisseau sanguin pathologie

    Mots-clés Pascal anglais : Malignant hypertension, Association, Pregnancy, Public inquiry, Oral administration, Contraceptive, Comparative study, Evaluation, Human, Female, Cardiovascular disease, Vascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0461369

    Code Inist : 002B20F02. Création : 03/02/1998.