Malignant hypertension in young women is related to previous hypertension in pregnancy, not oral contraception.
Previous studies have suggested that one-third of women of childbearing age who develop malignant phase hypertension (MHT) are likely to be taking oral contraceptives (OC).
We surveyed 104 women with a history of MHT.
None of the 65 aged>45 years were taking OC or other sex hormones.
Thirty-nine (mean age 34.9 years, SD 8.0) were aged 15-44 years at presentation : 22 Caucasian, 10 Black/Afro-Caribbean and seven Indo-Asian.
Of these 39,22 had a history of hypertension in pregnancy (group 1), and 17 did not (group 2).
Three of group 1 also had a history of OC-induced hypertension.
None were pregnant, but one was taking an OC at presentation with MHT.
Blood pressures at presentation and follow-up, and mean serum urea and creatinine at presentation were similar between groups, as was median survival (96 vs. 47 months, Lee-Desu statistic 0.75, p=0.38).
There was a trend towards poorer renal function at follow-up in group 1 patients, with higher mean serum urea and creatinine levels.
The causes of death were renal failure (5), stroke (4) and heart disease (2).
The OC was not a common cause of MHT amongst our sample of women of childbearing age, but a past history of hypertension in pregnancy was important.
Such patients also had a longer duration of hypertension and poorer renal function at follow-up.
Mots-clés Pascal : Hypertension artérielle maligne, Association, Gestation, Enquête publique, Voie orale, Contraceptif, Etude comparative, Evaluation, Homme, Femelle, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Malignant hypertension, Association, Pregnancy, Public inquiry, Oral administration, Contraceptive, Comparative study, Evaluation, Human, Female, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0461369
Code Inist : 002B20F02. Création : 03/02/1998.