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  1. Insulin resistance implications for type II diabetes mellitus and coronary heart disease.

    Article - En anglais


    To review information on the implications of insulin resistance for type II diabetes mellitus (non-insulin-dependent diabetes mellitus) and coronary heart disease, and to derive guidance from this information for the management of these conditions.


    A MEDLINE search of English-language articles published between 1985 and July 1996, and review of the bibliographies of articles obtained through the MEDLINE search and textbooks.


    Primary research articles, reviews and perspectives on the epidemiology of diabetes and cardiovascular diseases and on intervention outcomes in these diseases.


    Study design and quality were assessed, with particular attention to methods, study population size and other characteristics.

    Conclusions of review articles and perspectives were analyzed critically.


    Type II diabetes is associated with a two-to fourfold excess of coronary heart disease, compared to nondiabetic populations.

    In most studies, glycemia and duration of clinical diabetes were found to be only weak risk factors for coronary heart disease.

    Conventional coronary heart disease risk factors such as dyslipidemia and hypertension have been associated with coronary heart disease in type II diabetes subjects.

    Hyperinsulinemia and insulin resistance have been predictive of the development of type II diabetes and, in some studies, of coronary heart disease. (...)

    Mots-clés Pascal : Diabète non insulinodépendant, Cardiopathie, Epidémiologie, Insuline, Résistance, Etiologie, Communication information, Revue bibliographique, Facteur risque, Prévention, Homme, Endocrinopathie, Appareil circulatoire pathologie, Cardiopathie coronaire, Organisation santé, Hormone protéine, Hormone pancréatique, Hypoglycémiant

    Mots-clés Pascal anglais : Non insulin dependent diabetes, Heart disease, Epidemiology, Insulin, Resistance, Etiology, Information communication, Bibliographic review, Risk factor, Prevention, Human, Endocrinopathy, Cardiovascular disease, Coronary heart disease, Public health organization, Protein hormone, Pancreatic hormone, Hypoglycemic agent

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0461278

    Code Inist : 002B02O. Création : 03/02/1998.