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  1. The smaller size of the'coeliac iceberg'in adults.

    Article - En anglais

    Background 

    Since it has been ascertained that the prevalence of coeliac disease in the general paediatric population is 3.3 per 1000, we decided to evaluate this prevalence in the general adult population.

    Methods 

    Two thousand two hundred and thirty-seven adult subjects aged 20-87 years, representative of a population with sociodemographic characteristics typical of Western European countries with regard to sex and age, were studied.

    In all serum IgA antiendomysial antibodies (EMA) were searched for, and all patients who turned out to be positive underwent intestinal biopsy.

    Results 

    Four symptomless subjects aged between 20 and 39 years proved positive at the IgA EMA screening.

    The intestinal biopsy confirmed coeliac disease in all of them.

    The prevalence in our study group was, therefore, 1.8 per 1000.

    Conclusions 

    This study shows that the size of the submerged part of the'coeliac iceberg'is perhaps smaller in the adult population and suggests a linear trend towards a lower coeliac disease prevalence as age increases.

    Mots-clés Pascal : Coeliaque maladie, Epidémiologie, Prévalence, IgA, Anticorps, Critère âge, Etude comparative, Evaluation, Homme, Adulte, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale, Immunopathologie, Activité biologique

    Mots-clés Pascal anglais : Coeliac disease, Epidemiology, Prevalence, IgA, Antibody, Age criterion, Comparative study, Evaluation, Human, Adult, Digestive diseases, Intestinal disease, Intestinal malabsorption, Immunopathology, Biological activity

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0461201

    Code Inist : 002B13B03. Création : 03/02/1998.