Objectives-The diagnostic implications of finding non-fibrous inorganic particles in bronchoalveolar lavage (BAL) fluid has not been fully assessed.
The aim of this study has been to measure the silica and non-fibrous silicates in BAL fluid from populations with different exposures to inorganic dust, and to find whether such measurement is useful for diagnostic purposes.
Materials and methods-BAL samples from 19 subjects with only environmental exposure to inorganic dust (group A, mean (SD) age 50.7 (15.2)), 23 subjects with normal chest x ray films exposed to silica or silicates at work (group B, mean (SD) age 52.0 (12.4)), and 15 subjects with a previous diagnosis of silicosis (group C, mean (SD) age 68.0 (6.5)) were studied.
Absolute and relative cell counts were found, and the samples were prepared for microanalysis by electron microscopy (EM).
Firstly, semiquantitative x ray microanalysis was performed to find the level of silicon (Si) (peaklbackground Si) and this was followed by microanalysis of individual particles by EM.
Variables related to the level of Si detected were assessed with multivariate analysis.
Detected levels were higher in group B (2.09,95% confidence interval (95% CI) 1.56 to 2.82) and C (1.50,95% CI 1.07 to 2.12) than in group A (0.87,95% CI 0.66 to 1.16) (P<0.05, Dunett t test). (...)
Mots-clés Pascal : Silice, Silicate, Poussière, Diagnostic, Exposition professionnelle, Médecine travail, Homme, Lavage bronchoalvéolaire, Identification, Analyse quantitative, Microscopie électronique, Silicose, Pneumoconiose, Toxicité
Mots-clés Pascal anglais : Silica, Silicates, Dust, Diagnosis, Occupational exposure, Occupational medicine, Human, Bronchoalveolar lavage, Identification, Quantitative analysis, Electron microscopy, Silicosis, Pneumoconiosis, Toxicity
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0460656
Code Inist : 002B03L03. Création : 03/02/1998.