The relation between lifetime cumulative exposure to asbestos, pathological grade of pulmonary fibrosis, and lung burden of asbestos at death, was explored in a necropsy population of former workers in a chrysotile asbestos textile plant in South Carolina.
Methods-Estimates of cumulative, mean, and peak exposures to asbestos were available for 54 workers.
Necropsy records and lung tissue samples were obtained from hospital files.
Matched control cases were selected from consecutive necropsies performed at the same hospitals.
The extent and severity of pulmonary fibrosis was graded on tissue sections.
Mineral fibres in lung tissue were characterised by transmission electron microscopy combined with x ray spectroscopy.
A significant positive correlation (r=0.67, P<0.0001) was found between lifetime cumulative exposure to asbestos and total lung burden of asbestos fibres.
This relation was also found for the individual types of asbestos associated with the exposure : chrysotile and tremolite.
Pulmonary fibrosis was correlated with both cumulative exposure to asbestos (r=0.60, P<0.01) and the concentration of asbestos fibres in the lung (r=0.62, P<0.0001).
The concentration of tremolite fibres in the lung provided a better estimate of lung fibrosis than did the concentration of chrysotile.
Asbestosis was usually present in asbestos textile workers with more than 20 fibre-years cumulative exposure. (...)
Mots-clés Pascal : Amiante, Fibre minérale, Chrysotile, Asbestose, Fibrose, Poumon, Exposition professionnelle, Médecine travail, Homme, Toxicité, Relation dose réponse, Dose cumulée, Indice gravité, Caroline du Nord, Etats Unis, Amérique du Nord, Amérique, Appareil respiratoire pathologie, Pneumoconiose, Maladie professionnelle, Poumon pathologie, Tumeur maligne, Epidémiologie, Industrie textile
Mots-clés Pascal anglais : Asbestos, Mineral fiber, Asbestosis, Fibrosis, Lung, Occupational exposure, Occupational medicine, Human, Toxicity, Dose activity relation, Cumulated dose, Severity score, North Carolina, United States, North America, America, Respiratory disease, Pneumoconiosis, Occupational disease, Lung disease, Malignant tumor, Epidemiology, Textile industry
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0460655
Code Inist : 002B03L03. Création : 03/02/1998.