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  1. Relationship between head growth and neurodevelopmental outcome of Malaysian very low birthweight infants during the 1st year of life.

    Article - En anglais

    A prospective study was carried out to (i) compare head growth patterns of 103 very low birthweight (VLBW,<1500 g) Malaysian infants and 98 normal birthweight (NBW, 2500-<4500 g) controls during the 1st year of life ; and (ii) examine the relationship between neurodevelopmental outcome at 1 year of age and occipito-frontal head circumferences (OFC) at birth and at 1 year of age in VLBW babies.

    When compared with those of NBW infants at birth, mid-infancy and 1 year of age, the mean OFC ratios (observed/expected OFC at 50th percentile) of VLBW infants were significantly lower (p<0.001).

    Small-for-gestational-age (SGA) VLBW babies had significantly lower mean OFC ratios than their appropriate-for-gestational-age (AGA) VLBW counterparts at birth (p<0.001), but this difference was no longer seen at mid-infancy or at 1 year of age.

    Logistic regression analysis showed that abnormal late neonatal cranial ultrasound findings (odds ratio 8.5,95% confidence interval 4.12-22.07 ; p<0.001) and each additional day of oxygen therapy (odds ratio 1.15,95% confidence interval 1.00-4.45 ; p=0.045) were significant risk factors associated with neurodevelopmental disability at 1 year of age, while mean OFC ratios at birth or at 1 year of age were not.

    Poor postnatal head growth per se did not predict disability, but probably reflected the consequences of « brain injury » as evidenced by abnormal brain scans.

    Mots-clés Pascal : Poids naissance très faible, Nourrisson, Homme, Biométrie corporelle, Tête, Développement psychomoteur, Malaisie, Asie, Epidémiologie

    Mots-clés Pascal anglais : Very low birthweight, Infant, Human, Corporal biometry, Head, Psychomotor development, Malaysia, Asia, Epidemiology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0459182

    Code Inist : 002B30A01A2. Création : 03/02/1998.