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  1. The natural history of prostate carcinoma based on a Danish population treated with no intent to cure.

    Article - En anglais

    BACKGROUND

    Prostate carcinoma is one of the most commonly diagnosed cancers among Western males.

    In Denmark, the traditional therapeutic approach to prostate carcinoma regardless of tumor stage has been limited to palliative procedures.

    This conservative approach combined with a complete cancer and personal registration in Denmark provides an opportunity to describe the still debatable natural history of prostate carcinoma.

    METHODS

    The data, originating from hospital records and death certificates, included a complete prostate carcinoma population residing in Aarhus County diagnosed between January 1,1979 and December 31,1983.

    The patients were retrospectively followed from diagnosis until death (median length of follow-up, 15.0 years).

    RESULTS

    The total number of 719 new cases of prostate cancer were diagnosed without any screening programs.

    Forty-five percent of patients were diagnosed incidentally, and 31% of all patients had organ-confined disease (T1a-T2, Nx, M0).

    The disease specific survival rates at 1,5, and 10 years were 80%, 38%, and 17%, respectively, and 62% of the patients died primarily of prostate carcinoma.

    A multivariate analysis demonstrated a statistically significant relationship between disease specific death and T classification, tumor differentiation, and erythrocyte sedimentation rate at diagnosis. (...)

    Mots-clés Pascal : Carcinome, Prostate, Traitement palliatif, Histoire, Epidémiologie, Pronostic, Danemark, Europe, Homme, Tumeur maligne, Prostate pathologie, Appareil génital mâle pathologie, Appareil urinaire pathologie

    Mots-clés Pascal anglais : Carcinoma, Prostate, Palliative treatment, History, Epidemiology, Prognosis, Denmark, Europe, Human, Malignant tumor, Prostate disease, Male genital diseases, Urinary system disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0455760

    Code Inist : 002B14D02. Création : 03/02/1998.