A number of studies have been conducted in recent years investigating the potential effects on various health endpoints of the combination of noise and a variety of different industrial substances.
This review indicates that the information available in both animals and humans on this subject is limited particularly with respect to assessing occupational risk.
Most studies have focused on auditory effects in animals, although investigations have been performed for other toxicological endpoints.
For some substances, notably toluene, the information from animals studies does suggest an interaction but these were performed only at exposure levels to both noise and chemicals which were each individually ototoxic.
Single simultaneous exposure to noise and styrene did not result in any enhancement of auditory impairment above that produced by noise or styrene alone.
Single simultaneous exposure to noise and carbon monoxide (CO), however, showed some evidence of enhancement of ototoxicity beyond that produced by noise or carbon monoxide alone, although only at high atmospheric concentrations of CO.
When 1,3-dinitrobenzene was administered parentally at neurotoxic dose levels with continuous noise exposure, there was an increased severity of effects in the brain stem.
Combined exposure to noise and lead and/or cadmium resulted in histopathological heart lesions of undefined severity, a finding which was not observed for either of those agents in isolation. (...)
Mots-clés Pascal : Composé chimique, Industrie, Exposition professionnelle, Homme, Association, Nuisance acoustique, Trouble dû au bruit, Médecine travail, Animal, Encéphale, Coeur, Solvant organique, Toxicité, Tératogène, Article synthèse
Mots-clés Pascal anglais : Chemical compound, Industry, Occupational exposure, Human, Association, Noise pollution, Acoustic trauma, Occupational medicine, Animal, Brain (vertebrata), Heart, Organic solvent, Toxicity, Teratogen, Review
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0455117
Code Inist : 002B03L01. Création : 03/02/1998.