The 20210 A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis.
A dimorphism in the 3'-untranslated region of the prothrombin gene (G to A transition at position 20210) has recently been reported to be associated with increases in plasma prothrombin levels and in the risk of venous thrombosis (1).
We have examined the prothrombin dimorphism among 99 unselected outpatients with phlebography verified deep venous thrombosis, and in 282 healthy controls.
The prevalence of the 20210 A allele was 7.1% (7/99) in the patient group, and 1.8% (5/282) in the healthy control group (p=0.0095).
The relative risk of venous thrombosis was calculated to be 4.2 (95% Cl, 1.3 to 13.6), and was still significant when adjustment was made for age, sex and the factor V : R506Q mutation causing APC resistance [odds ratio 3.8 (95% Cl, 1.1 13.2) ]. As previously reported, 28% of the patients were carriers of the factor V : R506Q mutation.
Thus, 34% (one patient carried both traits) of unselected patients with deep venous thrombosis were carriers of an inherited prothrombotic disorder.
To sum up, our results confirm the 20210 A allele of the prothrombin gene to be an important risk factor for venous thrombosis.
Mots-clés Pascal : Thrombose profonde, Veine, Facteur risque, Prothrombine, Dimorphisme, Gène, Variant génétique, Epidémiologie, Suède, Europe, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Veine pathologie
Mots-clés Pascal anglais : Deep vein thrombosis, Vein, Risk factor, Prothrombin, Dimorphism, Gene, Genetic variant, Epidemiology, Sweden, Europe, Human, Cardiovascular disease, Vascular disease, Venous disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0450918
Code Inist : 002B12B03. Création : 03/02/1998.