Coagulation factor VII, serum-triglycerides and the R/Q353 polymorphism : Differences between older men and women.
Coagulation factor VII activity (FVII : C) is a risk indicator for cardiovascular disease.
It is related to serum-triglycerides and the R/Q353 polymorphism (alleles R and Q) in the gene coding for factor VII is strongly associated with factor VII.
The association of serum-triglycerides with factor VII may differ between the genotypes, but the results of earlier studies were inconsistent and did not include older people.
We studied FVII, triglycerides and the R/Q353 polymorphism in the Rotterdam Study.
In 1158 older subjects (489 men and 669 women) FVII : C, factor Vll : Chr, serum-triglycerides and the R/Q353-genotype were determined.
In women triglycerides were positively associated with FVII : Chr and FVII : C (FVII : Chr : bêta=12.4% PP/mmol/L, Cl : 10.3-14.5 ; FVII : C : bêta=13.1% PP/mmol/L, Cl : 10.4-15.8).
These associations varied by genotype (FVII : Chr : RR : bêta=11.7, Cl : 9.6-13.8, RQ/QQ : bêta=7.9, Cl : 4.6-11.2 ; FVII : C : RR : bêta=12.5, Cl : 9.5-15.5, RQ/QQ : bêta=6.4, Cl : 1.4-11.4).
In men, the associations of FVII : Chr and FVII : C with triglycerides were weaker (FVII : Chr : bêta=5.9, CI : 4.1-7.7 ; FVII : C : bêta=8.7, Cl : 6.2-1 1.2).
There was no difference between the genotype groups.
These results suggest that only in older women the strength of the association of factor VII with serum-triglycerides varies according to genotype of the R/Q353 polymorphism.
Mots-clés Pascal : Proconvertine, Facteur coagulation, Triglycéride, Sérum, Variabilité génétique, Epidémiologie, Infarctus, Myocarde, Facteur risque, Etude comparative, Age, Mâle, Femelle, Pays Bas, Europe, Homme, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie
Mots-clés Pascal anglais : Factor VII, Coagulation factor, Triglyceride, Serum, Genetic variability, Epidemiology, Infarct, Myocardium, Risk factor, Comparative study, Age, Male, Female, Netherlands, Europe, Human, Cardiovascular disease, Coronary heart disease, Myocardial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0450916
Code Inist : 002B12A03. Création : 03/02/1998.