Cumulative effects of high cholesterol levels, high blood pressure, and cigarette smoking on carotid stenosis.
Background Single measurements of cardiovascular risk factors may not accurately reflect a person's past exposure to those risk factors.
We therefore studied the long-term associations of cardiovascular risk factors such as high serum cholesterol levels, high blood pressure, and cigarette smoking with the prevalence of carotid stenosis.
Methods We studied cross-sectional and longitudinal information from a sample of 429 men and 661 women in the Framingham Heart Study who underwent B-mode ultrasound measurements of the carotid artery.
Their mean age was 75 years, and each had attended most of the biennial clinic examinations over the 34 years before the carotid ultrasound study.
We used time-integrated measurements to assess the associations between various cardiovascular risk factors and the degree of carotid stenosis.
Results Moderate carotid stenosis (=25 percent) was present in 189 men and 226 women.
We assessed the odds ratios for this degree of stenosis as compared with minimal stenosis (<25 percent) according to increases in risk factors.
In the men, the odds ratio for moderate carotid stenosis associated with an increase of 20 mm Hg in systolic blood pressure was 2.11 (95 percent confidence interval, 1.51 to 2.97).
The odds ratio for an increase of 10 mg per deciliter (0.26 mmol per liter) in the cholesterol level was 1.10 (95 percent confidence interval, 1.03 to 1.16), and for an increase of five pack-years of smoking it was 1.08 (...)
Mots-clés Pascal : Sténose, Carotide, Etude transversale, Hypercholestérolémie, Association, Tabagisme, Hypertension artérielle, Facteur risque, Vieillard, Homme, Long terme, Lipide, Système nerveux pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Artère pathologie, Système nerveux central pathologie, Métabolisme pathologie, Dyslipémie, Hyperlipoprotéinémie
Mots-clés Pascal anglais : Stenosis, Carotid, Cross sectional study, Hypercholesterolemia, Association, Tobacco smoking, Hypertension, Risk factor, Elderly, Human, Long term, Lipids, Nervous system diseases, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease, Arterial disease, Central nervous system disease, Metabolic diseases, Dyslipemia, Hyperlipoproteinemia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0450493
Code Inist : 002B12B03. Création : 03/02/1998.